Have you tried running a Citrix published application with Windows 10 after modifying your DPI settings? Well, you may have notice that your application is scaled incorrectly and your cursor is a little off. If you have a user that MUST use a higher DPI setting, then you can run the following command on the user’s PC to fix the issue:

reg add "HKCU\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers" /v "C:\Program Files (x86)\Citrix\ICA Client\wfica32.exe" /t REG_SZ /d "~ WIN7RTM" /f

This command will automatically set the compatibility settings for “C:\Program Files (x86)\Citrix\ICA Client\wfica32.exe” and it will configure the EXE to run in compatibility mode for Windows 7.

However if you do not need to scale your published application, then you can run the following command to disable display scaling on high DPI settings for “C:\Program Files (x86)\Citrix\ICA Client\wfica32.exe”:

reg add "HKCU\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers" /v "C:\Program Files (x86)\Citrix\ICA Client\wfica32.exe" /t REG_SZ /d "~ HIGHDPIAWARE" /f